| Pathophysiology of cardiac transplantation and the challenge of exercise. | |
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MedLine Citation:
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PMID: 11142594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart transplantation is now currently performed in adult (A-HTR) as well as in pediatric cardiac patients (P-HTR). In A-HTR, heart denervation results in a delayed, blunted heart rate (HR) response to exercise onset, mainly sustained by the level of circulating catecholamines. At the offset of exercise HR resumes the pre-exercise level in 5-25 min, depending on the absolute work intensity. Peak HR is approximately 140 beats/min. Maximal aerobic power is 19 O2/kg x min, i.e., approximately 60% than that of healthy age-matched sedentary subjects and exercise tolerance is therefore reduced. A functional impairment at the muscle level may also be present, as suggested by the slow kinetics of the VO2 readjustment (phase II) at the onset of submaximal aerobic exercise. P-HTR generally behave as A-HTR. However, recently, in a few P-HTR a fast HR response to exercise and greater peak HR values (172 +/- 22 beats/min) were demonstrated. Maximal aerobic power of P-HTR was 32 +/- 7 ml O2/kg x min, greater than that of A-HTR, but yet approximately 60% of that of healthy age-matched controls. It may be concluded that occasionally P-HTR may resume an almost normal cardiovascular response to exercise; nevertheless, their exercise tolerance is limited, likely by functional impairment at the muscle level, whose origin is still unknown. |
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Authors:
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C Marconi |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of sports medicine Volume: 21 Suppl 2 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-01-04 Completed Date: 2001-03-22 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: Germany |
Other Details:
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Languages: eng Pagination: S106-8 Citation Subset: IM |
Affiliation:
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Institute of Advanced Biomedical Technologies, Section of Physiological Genomics, National Research Council, Milano, Italy. marconi@itba.mi.cnr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Exercise / physiology* Heart Rate Heart Transplantation / physiology* Humans Pulmonary Gas Exchange |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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