| Pathophysiology of antihypertensive therapy with diuretics. | |
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MedLine Citation:
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PMID: 17249519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent progress in antihypertensive therapy has widened the selection of drugs, and large clinical trials have attracted attention to newer classes of antihypertensives. Consequently, the use of diuretics as antihypertensive agents has been relatively reduced, particularly since the newer drugs are associated with fewer adverse metabolic reactions. However, diuretics have a specific activity of removing sodium from the body fluid, thereby rendering the blood pressure insensitive to sodium intake, relieving the overload to systemic circulation, and normalizing the circadian rhythm of blood pressure from a non-dipper to a dipper pattern. At low doses, diuretics are known to be as effective as all other antihypertensive agents for reducing nearly all types of cardiovascular events. In this brief review, the indication for thiazide diuretics will be discussed based on the pathophysiology of hypertension and antihypertensive therapy with diuretics mainly from the point of view of sodium metabolism. Low-dose diuretics will continue to be an important agent in the treatment of hypertension, mostly in combination with vasodilators such as modulators of the reninangiotensin system and calcium channel blockers. |
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Authors:
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Michio Fukuda; Genjiro Kimura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 29 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2007-01-25 Completed Date: 2007-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
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Languages: eng Pagination: 645-53 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Blood Pressure / drug effects Circadian Rhythm Diuretics / pharmacology, therapeutic use* Drug Therapy, Combination Humans Hypertension / drug therapy*, urine Natriuresis / drug effects Sodium / urine |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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