Document Detail

Pathophysiology of angina.
MedLine Citation:
PMID:  1967428     Owner:  NLM     Status:  MEDLINE    
The development and pathophysiology of myocardial ischaemia is a dynamic process in which increased myocardial oxygen demand or decreased coronary blood flow are not the sole determinants. Both these factors are inappropriately altered before, during, or after the onset of ischaemia, and a vicious cycle ensues. Drug therapy should be aimed at not only preventing the development of myocardial ischaemia but also at reversing the abnormal hormonal, metabolic, and haemodynamic effects.
P Collins; K M Fox
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lancet     Volume:  335     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-20     Completed Date:  1990-02-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  94-6     Citation Subset:  AIM; IM    
National Heart Hospital, London, UK.
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MeSH Terms
Angina Pectoris / etiology,  metabolism,  physiopathology*
Blood Pressure
Cardiomyopathies / complications*,  metabolism,  physiopathology,  prevention & control
Catecholamines / physiology
Coronary Circulation
Nitric Oxide / physiology
Oxygen Consumption
Platelet Aggregation / physiology
Vasoconstriction / physiology
Vasodilation / physiology
Reg. No./Substance:
0/Catecholamines; 10102-43-9/Nitric Oxide

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