| Pathophysiology after pylorus-preserving pancreatoduodenectomy: a comparative study of pancreatogastrostomy and pancreatojejunostomy. | |
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MedLine Citation:
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PMID: 10370688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Pylorus-preserving pancreatoduodenectomy using the pancreatogastrostomy technique may result in pancreatic exocrine insufficiency and obstruction of the pancreatic duct. A prospective randomized comparison of pancreatogastrostomy and pancreatojejunostomy was therefore performed to assess pathophysiologic changes after pylorus-preserving pancreatoduodenectomy. METHODOLOGY: The study population consisted of 23 patients (pancreatogastrostomy: 10, pancreatojejunostomy: 13) who were observed for 2 years. RESULTS: Neither physical condition (dietary intake, body weight, performance status, and frequency of bowel movements) nor nutritional parameters (serum levels of total protein, albumin, total cholesterol, and cholinesterase) differed significantly between the two groups; these parameters recovered to pre-operative levels within 1 year in both groups. Changes in pancreatic function diagnosis (PFD) test results were similar between the two groups. The glucose tolerance test results revealed deterioration of glucose tolerance in 2 patients (20%) in the pancreatogastrostomy group and 3 patients (23%) in the pancreatojejunostomy group. In 2 of 3 patients in each group with non-dilated pancreatic ducts before surgery, the pancreatic ducts dilated after surgery. Diabetes developed after surgery in one such patient in each group. No significant differences were observed between the two groups with respect to changes in glucose tolerance test results and the diameter of the pancreatic duct. CONCLUSIONS: This prospective randomized study demonstrates no difference in pathophysiologic changes between patients undergoing pancreatogastrostomy or pancreatojejunostomy after pylorus-preserving pancreatoduodenectomy, at least in the first 2 years. |
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Authors:
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M Konishi; M Ryu; T Kinoshita; K Inoue |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 46 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 1999 Mar-Apr |
Date Detail:
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Created Date: 1999-08-13 Completed Date: 1999-08-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: GREECE |
Other Details:
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Languages: eng Pagination: 1181-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, National Cancer Center Hospital East, Kashiwa, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Ampulla of Vater / physiopathology, surgery* Common Bile Duct Neoplasms / physiopathology, surgery* Female Follow-Up Studies Gastrostomy / methods* Glucose Tolerance Test Humans Male Middle Aged Pancreatic Ducts / physiopathology Pancreatic Function Tests Pancreaticoduodenectomy / methods* Pancreaticojejunostomy / methods* Postoperative Complications / physiopathology* Prospective Studies Pylorus / surgery* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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