Document Detail


Pathophysiology of acute pancreatitis: evaluation of the effect and mode of action of steroids in experimental pancreatitis in dogs.
MedLine Citation:
PMID:  7091513     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three experiments were performed to evaluate the effects and hemodynamic changes brought about by steroids in experimental pancreatitis in dogs. The results show (1) a significant improval in survival in steroid-treated groups, (2) no difference in cardiac output or mean blood pressure between groups, (3) a decrease in relative pancreatic arterial blood flow in the untreated animals, and (4) an increase in arterial flow to the pancreas after steroid therapy. The experiments suggest that the reversal of reduced pancreatic flow may be important in improving the prognosis.
Authors:
J G Studley; W G Schenk
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of surgery     Volume:  143     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-08-07     Completed Date:  1982-08-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  761-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Blood Circulation / drug effects
Blood Pressure / drug effects
Cardiac Output / drug effects
Dogs
Hydrocortisone / pharmacology,  therapeutic use
Pancreatitis / drug therapy,  physiopathology*
Grant Support
ID/Acronym/Agency:
AM-26186/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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