Document Detail


Pathophysiology of acute coronary syndrome assessed by optical coherence tomography.
MedLine Citation:
PMID:  20554431     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Optical coherence tomography (OCT) is an optical analogue of intravascular ultrasound (IVUS), which provides high-resolution images of the coronary arteries up to 10microm. OCT allows us to demonstrate clearly culprit lesion morphologies in detail including types of plaque, plaque disruption, thrombus, fibrous cap thickness, and the frequency of thin-capped fibroatheroma (TCFA) in acute coronary syndrome (ACS), as described in previous histological examinations. Furthermore, clinical silent disrupted plaques and non-ruptured TCFAs, which are thought to be precursors of ACS and vulnerable plaques, have also been demonstrated by OCT not only in culprit but also in non-culprit vessels in ACS. OCT also identified the mechanisms of late thrombosis after bare-metal stent and drug-eluting stent implantation. Development of the next-generation frequency-domain OCT system and prospective studies in a large population may allow us to realize the pathophysiology of ACS in detail in vivo in humans, and these may provide us new insights into the etiology and treatment of coronary artery disease in the near future for predicting and preventing ACS.
Authors:
Takashi Akasaka; Takashi Kubo; Masato Mizukoshi; Atsushi Tanaka; Hironori Kitabata; Takashi Tanimoto; Toshio Imanishi
Publication Detail:
Type:  Journal Article; Review     Date:  2010-06-15
Journal Detail:
Title:  Journal of cardiology     Volume:  56     ISSN:  0914-5087     ISO Abbreviation:  J Cardiol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  8-14     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Cardiovascular Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan. akasat@wakayama-m.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / physiopathology*
Coronary Vessels / physiopathology
Humans
Tomography, Optical Coherence*

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