| Pathophysiology of achalasia. | |
| | |
MedLine Citation:
|
PMID: 10980949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Achalasia is a rare but important condition affecting the myenteric neurons of the esophagus. A number of studies have provided evidence for the preservation of cholinergic innervation to the esophagus in achalasia. This forms the rationale for the treatment of achalasia with botulinum toxin. Identification of nitric oxide as the primary inhibitory neurotransmitter of the gastrointestinal tract has improved our understanding of the pathophysiology of primary achalasia. Neurons containing nitric oxide are absent within the myenteric plexuses of patients with achalasia, and the experimental inhibition of nitric oxide produces a picture that manometrically mimics achalasia. Recent advances have provided insights into the genetic basis and pathogenesis of a growing number of secondary forms of achalasia. Examples of such secondary disorders include Allgrove's syndrome, autoimmune polyglandular syndrome, and multiple endocrine neoplasia type 2B. |
| | |
Authors:
|
I Hirano |
Related Documents
:
|
11032679 - Multiple endocrine neoplasia in a dog. 17013909 - Neurofilament heavy-chain nfh(smi35) in cerebrospinal fluid supports the differential d... 2799659 - The nevoid basal cell carcinoma syndrome--gorlin's syndrome. multiple jaw cysts and ski... 11504039 - Correspondence of soldier defense secretion mixtures with cuticular hydrocarbon phenoty... 957339 - Inhibition of multiple ovulation in hypophysectomized hens treated with gonadotrophins. 8672769 - Hepatic angiomyelolipoma and tuberous sclerosis. 8403629 - Eosinophilia-myalgia syndrome: a clinicopathological study of four patients. 20950399 - An autosomal recessive syndrome of severe cognitive impairment, dysmorphic facies and s... 10332179 - Rescue and salvage of casualties suffering from the crush syndrome after mass disasters. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current gastroenterology reports Volume: 1 ISSN: 1522-8037 ISO Abbreviation: Curr Gastroenterol Rep Publication Date: 1999 Jun |
Date Detail:
|
Created Date: 2000-11-15 Completed Date: 2000-11-15 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 100888896 Medline TA: Curr Gastroenterol Rep Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 198-202 Citation Subset: IM |
Affiliation:
|
Northwestern University Medical School, Division of Gastroenterology and Hepatology, Searle 10-563, 303 East Chicago Avenue, Chicago, IL 60611, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Diagnosis, Differential Esophageal Achalasia / diagnosis, physiopathology*, therapy Esophagus / innervation Humans Myenteric Plexus / physiopathology Neurons / physiology Nitric Oxide / physiology |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuromuscular control of esophageal peristalsis.
Next Document: Advances in minimally invasive esophageal surgery.