| Pathophysiology of Pulmonary Hypertension in Acute Lung Injury. | |
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MedLine Citation:
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PMID: 22246001 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Acute lung injury (ALI) and acute respiratory distress syndrome are characterized by protein rich alveolar oedema, reduced lung compliance and acute severe hypoxemia. A degree of pulmonary hypertension (PH) is also characteristic, higher levels of which are associated with increased morbidity and mortality. The increase in right ventricular (RV) afterload causes RV dysfunction and failure in some patients, with associated adverse effects on oxygen delivery. Although the introduction of lung protective ventilation strategies has probably reduced the severity of PH in ALI, a recent invasive hemodynamic analysis suggests that even in the 'modern era', its presence remains clinically important. We therefore sought to summarize current knowledge of the pathophysiology of PH in ALI. |
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Authors:
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Laura C Price; Daniel F McAuley; Philip S Marino; Simon J Finney; Mark J Griffiths; Stephen J Wort |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: American journal of physiology. Lung cellular and molecular physiology Volume: - ISSN: 1522-1504 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901229 Medline TA: Am J Physiol Lung Cell Mol Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Royal Brompton Hospital. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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