Document Detail


Pathophysiology and possible iatrogenic cause of leiomyomatosis peritonealis disseminata.
MedLine Citation:
PMID:  20068330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a case of leiomyomatosis peritonealis disseminata (LPD) after myoma morcellation and review the literature using the keywords leiomyomatosis peritonealis disseminata and disseminated peritoneal leiomyomatosis. The search was conducted in Medline, EMBASE, and Cochrane Database of systematic reviews. We encountered 132 cases of LPD in the English literature; 113 in the reproductive age group, 7 in postmenopausal women, 6 in males, and another in a horse. The possible causes could be divided into hormonal, subperitoneal mesenchymal stem cells, metaplasia, genetic, or iatrogenic after morcellation of myoma during laparoscopic surgery. Our case and 4 others reported in the literature support the contribution of the iatrogenic theory. It appears that LPD could be due to metaplasia of mesenchymal cells of the peritoneum and, in susceptible women, leaving fragments of myoma in the abdominal cavity might contribute to the development of LPD. Accordingly, one should avoid leaving fragments of the uterus or myoma tissue in the abdominal cavity after morcellation.
Authors:
Ayman Al-Talib; Togas Tulandi
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-01-12
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  69     ISSN:  1423-002X     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-03     Completed Date:  2010-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 S. Karger AG, Basel.
Affiliation:
Department of Obstetrics and Gynecology, McGill University, Montreal, Que., Canada.
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MeSH Terms
Descriptor/Qualifier:
Diagnosis, Differential
Female
Gynecologic Surgical Procedures / adverse effects,  methods
Humans
Iatrogenic Disease*
Leiomyoma / surgery*
Leiomyomatosis / diagnosis,  etiology*,  surgery
Middle Aged
Myoma / surgery
Peritoneal Neoplasms / diagnosis,  etiology*,  surgery
Uterine Cervical Neoplasms / surgery
Uterine Neoplasms / surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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