Document Detail


Pathophysiology of Parkinson's disease.
MedLine Citation:
PMID:  10349507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parkinson's disease is a progressive disease with selective dopaminergic neuronal loss. The pathophysiology is at present better understood with plurifactorial etiology, including genetic predisposition and environmental toxic factors. The mechanisms of cell death are based upon oxidative stress and apoptosis. The heterogeneity of dopaminergic neuronal loss leads to etiopathogenic clues. In the same way, the model of functional organization of basal ganglia circuitry gives a basis for further experimental and therapeutic research.
Authors:
A M Bonnet; J L Houeto
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  53     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-21     Completed Date:  1999-07-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  117-21     Citation Subset:  IM    
Affiliation:
Hôpital de la Pitié-Salpêtrière, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / physiology*
Basal Ganglia / pathology
Brain Chemistry / physiology*
Environmental Pollutants / toxicity
Humans
Oxidative Stress / physiology
Parkinson Disease / etiology,  genetics,  pathology,  physiopathology*
Receptors, Dopamine / physiology
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Receptors, Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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