Document Detail


Pathophysiology of myocardial injury and remodeling: implications for molecular imaging.
MedLine Citation:
PMID:  20395340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite advances in reperfusion therapy, acute coronary syndromes can still result in myocardial injury and subsequent myocardial infarction (MI). Molecular, cellular, and interstitial events antecedent to the acute MI culminate in deleterious changes in the size, shape, and function of the left ventricle (LV), collectively termed LV remodeling. Three distinct anatomic and physiologic LV regions can be described after MI: the infarct, border zone, and remote regions. Given the complexity of post-MI remodeling, imaging modalities must be equally diverse to elucidate this process. The focus of this review will first be on cardiovascular MRI of the anatomic and pathophysiologic LV regions of greatest interest with regard to the natural history of the post-MI remodeling process. This review will then examine imaging modalities that provide translational and molecular insight into burgeoning treatment fields for the attenuation of post-MI remodeling, such as cardiac restraint devices and stem cell therapy.
Authors:
Jennifer A Dixon; Francis G Spinale
Publication Detail:
Type:  Journal Article; Review     Date:  2010-04-15
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  51 Suppl 1     ISSN:  1535-5667     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-11     Completed Date:  2010-06-03     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  102S-106S     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Biophysics / methods
Cardiology / methods
Diagnostic Imaging / methods*
Heart / physiology
Heart Ventricles / pathology*
Humans
Magnetic Resonance Imaging / methods
Myocardium / pathology*
Prognosis
Reperfusion
Stem Cells / cytology
Ventricular Remodeling / physiology*
Grant Support
ID/Acronym/Agency:
R01 HL059165/HL/NHLBI NIH HHS; R01 HL059165-12/HL/NHLBI NIH HHS
Comments/Corrections

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