| Pathophysiology of myocardial injury and remodeling: implications for molecular imaging. | |
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MedLine Citation:
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PMID: 20395340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite advances in reperfusion therapy, acute coronary syndromes can still result in myocardial injury and subsequent myocardial infarction (MI). Molecular, cellular, and interstitial events antecedent to the acute MI culminate in deleterious changes in the size, shape, and function of the left ventricle (LV), collectively termed LV remodeling. Three distinct anatomic and physiologic LV regions can be described after MI: the infarct, border zone, and remote regions. Given the complexity of post-MI remodeling, imaging modalities must be equally diverse to elucidate this process. The focus of this review will first be on cardiovascular MRI of the anatomic and pathophysiologic LV regions of greatest interest with regard to the natural history of the post-MI remodeling process. This review will then examine imaging modalities that provide translational and molecular insight into burgeoning treatment fields for the attenuation of post-MI remodeling, such as cardiac restraint devices and stem cell therapy. |
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Authors:
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Jennifer A Dixon; Francis G Spinale |
Publication Detail:
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Type: Journal Article; Review Date: 2010-04-15 |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 51 Suppl 1 ISSN: 1535-5667 ISO Abbreviation: J. Nucl. Med. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-11 Completed Date: 2010-06-03 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 102S-106S Citation Subset: IM |
Affiliation:
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Division of Cardiothoracic Surgery, Medical University of South Carolina, and Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Biophysics / methods Cardiology / methods Diagnostic Imaging / methods* Heart / physiology Heart Ventricles / pathology* Humans Magnetic Resonance Imaging / methods Myocardium / pathology* Prognosis Reperfusion Stem Cells / cytology Ventricular Remodeling / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL059165-12/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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