| Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops? | |
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MedLine Citation:
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PMID: 15699723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The association of Meniere's syndrome with endolymphatic hydrops has led to the formation of a central hypothesis: many possible etiologic factors lead to hydrops, and hydrops in turn generates the symptoms. However, this hypothesis of hydrops as being the final common pathway has not been proven conclusively. SPECIFIC AIM: To examine human temporal bones with respect to the role of hydrops in causing symptoms in Meniere's syndrome. If the central hypothesis were true, every case of Meniere's syndrome should have hydrops and every case of hydrops should show the typical symptoms. METHODS: Review of archival temporal bone cases with a clinical diagnosis of Meniere's syndrome (28 cases) or a histopathologic diagnosis of hydrops (79 cases). RESULTS: All 28 cases with classical symptoms of Meniere's syndrome showed hydrops in at least one ear. However, the reverse was not true. There were 9 cases with idiopathic hydrops and 10 cases with secondary hydrops, but the patients did not exhibit the classic symptoms of Meniere's syndrome. A review of the literature revealed cases with asymptomatic hydrops (similar to the current study), as well as cases where symptoms of Meniere's syndrome existed during life but no hydrops was observed on histology. We also review recent experimental data where obstruction of the endolymphatic duct in guinea pigs resulted in cytochemical abnormalities within fibrocytes of the spiral ligament before development of hydrops. This result is consistent with the hypothesis that hydrops resulted from disordered fluid homeostasis caused by disruption of regulatory elements within the spiral ligament. CONCLUSION: Endolymphatic hydrops should be considered as a histologic marker for Meniere's syndrome rather than being directly responsible for its symptoms. |
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Authors:
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Saumil N Merchant; Joe C Adams; Joseph B Nadol |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology Volume: 26 ISSN: 1531-7129 ISO Abbreviation: Otol. Neurotol. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-02-08 Completed Date: 2005-07-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100961504 Medline TA: Otol Neurotol Country: United States |
Other Details:
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Languages: eng Pagination: 74-81 Citation Subset: IM |
Affiliation:
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Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114-3096, USA. saumil_merchant@meei.harvard.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Animals Causality Child Comorbidity Disease Progression Ear, Inner / pathology Ear, Middle / pathology, physiopathology Endolymph / physiology Endolymphatic Hydrops / complications, epidemiology, physiopathology* Female Follow-Up Studies Guinea Pigs Hearing Loss, Sensorineural / epidemiology, etiology, physiopathology Humans Male Meniere Disease / epidemiology, etiology, physiopathology* Middle Aged Organ of Corti / pathology, physiopathology Postural Balance / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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