Document Detail

Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling.
MedLine Citation:
PMID:  23233080     Owner:  NLM     Status:  MEDLINE    
The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling system is a well-characterized modulator of cardiovascular function, in general, and blood pressure, in particular. The availability of mice mutant for key enzymes in the NO-cGMP signaling system facilitated the identification of interactions with other blood pressure modifying pathways (e.g. the renin-angiotensin-aldosterone system) and of gender-specific effects of impaired NO-cGMP signaling. In addition, recent genome-wide association studies identified blood pressure-modifying genetic variants in genes that modulate NO and cGMP levels. Together, these findings have advanced our understanding of how NO-cGMP signaling regulates blood pressure. In this review, we will summarize the results obtained in mice with disrupted NO-cGMP signaling and highlight the relevance of this pathway as a potential therapeutic target for the treatment of hypertension.
Robrecht Thoonen; Patrick Y Sips; Kenneth D Bloch; Emmanuel S Buys
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current hypertension reports     Volume:  15     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-06-24     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-58     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / physiology
Cyclic GMP / metabolism,  physiology*
Cyclic GMP-Dependent Protein Kinases / metabolism
Endothelium, Vascular / physiology
Genome-Wide Association Study
Hypertension / physiopathology*
Mice, Mutant Strains
Models, Animal
Nitric Oxide / metabolism,  physiology*
Signal Transduction / physiology
Vasoconstriction / physiology
Vasodilation / physiology
Grant Support
R01 EY022746/EY/NEI NIH HHS; R21 EY020987/EY/NEI NIH HHS
Reg. No./Substance:
31C4KY9ESH/Nitric Oxide; EC GMP-Dependent Protein Kinases; H2D2X058MU/Cyclic GMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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