| Pathophysiology of Hypertension in the Absence of Nitric Oxide/Cyclic GMP Signaling. | |
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MedLine Citation:
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PMID: 23233080 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling system is a well-characterized modulator of cardiovascular function, in general, and blood pressure, in particular. The availability of mice mutant for key enzymes in the NO-cGMP signaling system facilitated the identification of interactions with other blood pressure modifying pathways (e.g. the renin-angiotensin-aldosterone system) and of gender-specific effects of impaired NO-cGMP signaling. In addition, recent genome-wide association studies identified blood pressure-modifying genetic variants in genes that modulate NO and cGMP levels. Together, these findings have advanced our understanding of how NO-cGMP signaling regulates blood pressure. In this review, we will summarize the results obtained in mice with disrupted NO-cGMP signaling and highlight the relevance of this pathway as a potential therapeutic target for the treatment of hypertension. |
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Authors:
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Robrecht Thoonen; Patrick Y Sips; Kenneth D Bloch; Emmanuel S Buys |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-12 |
Journal Detail:
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Title: Current hypertension reports Volume: - ISSN: 1534-3111 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Molecular Cardiology Research Institute, Molecular Cardiology Research Center, Tufts Medical Center, 800 Washington Street, Box 80, Boston, MA 02111, USA, rthoonen@tuftsmedicalcenter.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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