Document Detail

Pathophysiological role of cytokines in congestive heart failure.
MedLine Citation:
PMID:  11160765     Owner:  NLM     Status:  MEDLINE    
Heart failure is a complex neurohumoral and inflammatory syndrome. Recent studies have shown that proinflammatory cytokines (interleukin-1, interleukin-2, interleukin-6, interleukin-10, and tumor necrosis factor) are involved in cardiac depression and in the complex syndrome of heart failure. Understanding the involvement of these cytokines may enable us to reverse cardiac depression and heart failure by the use of monoclonal antibodies directed against specific cytokines to block the downhill progression of heart failure.
A Blum; H Miller
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of medicine     Volume:  52     ISSN:  0066-4219     ISO Abbreviation:  Annu. Rev. Med.     Publication Date:  2001  
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985151R     Medline TA:  Annu Rev Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-27     Citation Subset:  IM    
Department of Internal Medicine, Poria Hospital, Lower Galilee 15208, Israel.
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MeSH Terms
Antibodies, Monoclonal / therapeutic use
Autonomic Nervous System / physiopathology
Cytokines / antagonists & inhibitors,  blood,  immunology*
Disease Models, Animal
Disease Progression
Heart Failure / blood,  immunology*,  physiopathology*,  therapy
Interleukin-1 / antagonists & inhibitors,  immunology*
Interleukin-10 / antagonists & inhibitors,  immunology*
Interleukin-2 / antagonists & inhibitors,  immunology*
Interleukin-6 / antagonists & inhibitors,  immunology*
Neurotransmitter Agents / physiology
Tumor Necrosis Factor-alpha / antagonists & inhibitors,  immunology*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Cytokines; 0/Interleukin-1; 0/Interleukin-2; 0/Interleukin-6; 0/Neurotransmitter Agents; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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