Document Detail

Pathophysiological changes associated with increasing grade of hepatic encephalopathy.
MedLine Citation:
PMID:  3241314     Owner:  NLM     Status:  MEDLINE    
The pathophysiological changes occurring with increasing grade of encephalopathy were examined in 93 consecutive episodes in 44 patients with liver cirrhosis (37 posthepatic). The incidence of gastrointestinal bleeding and leukocytosis increased significantly when the grade advanced from 1 to 5. The following variables showed a trend for change that did not reach statistical significance: rising serum bilirubin, SGOT, and BUN levels; decreasing serum sodium and chloride levels; and increased incidence of infection. The mean values of the following variables were significantly different in 25 fatal episodes and 68 survivors, implicating a bad prognosis: high serum bilirubin, alkaline phosphatase, and BUN levels; low serum albumin, sodium, and chloride levels; and a higher incidence of severe infections (sepsis, infected ascitic fluid). Because increasing grade of encephalopathy is the most important factor in determining the prognosis of hepatic encephalopathy (mortality 0, 10, 5, 19, and 85 percent in grades 1 to 5, respectively), more efforts should be made to understand and prevent the pathophysiological changes associated with advancing grades of encephalopathy.
R Eliakim; D Shouval; M Eliakim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  80     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1989-05-19     Completed Date:  1989-05-19     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  986-91     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Hepatic Encephalopathy / physiopathology*
Liver Function Tests
Middle Aged

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