| Pathophysiological aspects of cellular pyridine nucleotide metabolism: focus on the vascular endothelium. Review. | |
| | |
MedLine Citation:
|
PMID: 14594189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In recent years, pyridine nucleotides NAD(H) and NADP(H) have been established as an important molecules in physiological and pathophysiological signaling and cell injury pathways. Protein modification is catalyzed by ADP-ribosyl transferases that attach the ADP-ribose moiety of NAD+ to specific aminoacid residues of the acceptor proteins, with significant changes in the function of these acceptors. Mono(ADP-ribosyl)ation reactions have been implicated to play a role both in physiological responses and in cellular responses to bacterial toxins. Cyclic ADP-ribose formation also utilizes NAD+ and primarily serves as physiological, signal transduction mechanisms regulating intracellular calcium homeostasis. In pathophysiological conditions associated with oxidative stress (such as various forms of inflammation and reperfusion injury), activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) occurs, with subsequent, substantial fall in cellular NAD+ and ATP levels, which can determine the viability and function of the affected cells. In addition, NADPH oxidases can significantly affect the balance and fate of NAD+ and NADP in oxidatively stressed cells and can facilitate the generation of various positive feedback cycles of injury. Under severe oxidant conditions, direct oxidative damage to NAD+ has also been reported. The current review focuses on PARP and on NADPH oxidases, as pathophysiologically relevant factors in creating disturbances in the cellular pyridine nucleotide balance. A separate section describes how these mechanisms apply to the pathogenesis of endothelial cell injury in selected cardiovascular pathophysiological conditions. |
| | |
Authors:
|
Cs Szabó |
Related Documents
:
|
18678619 - Nonsteroidal anti-inflammatory drugs induced endothelial apoptosis by perturbing peroxi... 14676829 - Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear... 16581899 - Cytosine arabinoside induces programmed endothelial cell death through the caspase-3 pa... 17114439 - Cyclosporin a abolishes cd28-mediated resistance to cd95-induced apoptosis via superind... 9144569 - Apoptosis in the absence of poly-(adp-ribose) polymerase. 15911099 - Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia... 8352909 - Immunoregulation by cytokines. 21539469 - Augmentation of cellular immune response by ipomoea obscura and ipobscurine alkaloid at... 16329999 - Co from enhanced ho activity or from corm-2 inhibits both o2- and no production and dow... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Acta physiologica Hungarica Volume: 90 ISSN: 0231-424X ISO Abbreviation: Acta Physiol Hung Publication Date: 2003 |
Date Detail:
|
Created Date: 2003-11-03 Completed Date: 2004-06-09 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8309201 Medline TA: Acta Physiol Hung Country: Hungary |
Other Details:
|
Languages: eng Pagination: 175-93 Citation Subset: IM |
Affiliation:
|
Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary. szabocsaba@aol.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
ADP Ribose Transferases
/
metabolism Animals Cardiovascular Diseases / metabolism, physiopathology Endothelium, Vascular / metabolism, physiopathology* Humans Models, Biological NAD / metabolism* NADP / metabolism* NADPH Oxidase / metabolism Poly(ADP-ribose) Polymerases / metabolism |
| Chemical | |
Reg. No./Substance:
|
53-59-8/NADP; 53-84-9/NAD; EC 1.6.3.1/NADPH Oxidase; EC 2.4.2.-/ADP Ribose Transferases; EC 2.4.2.30/Poly(ADP-ribose) Polymerases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypnosis, attention, and time cognition.
Next Document: The effects of whole body vibration on humans: dangerous or advantageous?