Document Detail


Pathophysiological roles of NADPH oxidase/nox family proteins in the vascular system. -Review and perspective-.
MedLine Citation:
PMID:  21673456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.
Authors:
Tetsuro Ago; Junya Kuroda; Masahiro Kamouchi; Junichi Sadoshima; Takanari Kitazono
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-06-15
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-25     Completed Date:  2011-11-18     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1791-800     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Vessels / enzymology*
Humans
Mitochondria / metabolism*
NADPH Oxidase / metabolism*
Reactive Oxygen Species / metabolism*
Vascular Diseases / enzymology*
Grant Support
ID/Acronym/Agency:
R01 AG023039/AG/NIA NIH HHS; R01 HL067724/HL/NHLBI NIH HHS; R01 HL091469/HL/NHLBI NIH HHS; R01 HL102738/HL/NHLBI NIH HHS; R01 HL112330/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species; EC 1.6.3.1/NADPH Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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