Document Detail

Pathophysiologic significance of lung granulocytes in human adult respiratory distress syndrome induced by septic or traumatic shock.
MedLine Citation:
PMID:  3630524     Owner:  NLM     Status:  MEDLINE    
To evaluate the significance of lung granulocytes in the adult respiratory distress syndrome (ARDS), 12 ARDS patients were studied with bronchoalveolar lavage (BAL) within 4-12 hours after clinical diagnosis of the syndrome. The specificity of pulmonary granulocytes in ARDS was investigated in comparison with five patients requiring ventilator treatment for cardiogenic pulmonary oedema and 17 normal patients about to undergo cholecystectomy. The percentage of granulocytes among recovered BAL cells was significantly higher in ARDS (77 +/- 18, M +/- SD) than in the cardiac (7 +/- 4) or the normal (1.5 +/- 1.0) group. In serial BAL (48-hour intervals) in five ARDS patients, significant reduction of granulocytes 86 +/- 11----32 +/- 10%) accompanied clinical improvement. The percentage of granulocyte in BAL correlated significantly and inversely with the PaO2/FiO2 ratio (r = -0.98), and in ARDS it was significantly higher after septic than after traumatic shock (89 +/- 14 vs. 55 +/- 12). Myeloperoxidase, a specific constituent of neutrophils, was significantly and inversely correlated with PaO2/FiO2 ratio (r = -0.62). The findings suggest a role for activated granulocytes in the lung, with release of tissue-damaging substances, in initial ARDS pathogenesis, notably when the syndrome is sepsis-induced.
J Modig; R Hällgren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta chirurgica Scandinavica     Volume:  153     ISSN:  0001-5482     ISO Abbreviation:  Acta Chir Scand     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-09-28     Completed Date:  1987-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906530     Medline TA:  Acta Chir Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
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MeSH Terms
Granulocytes / immunology*
Lung / immunology*
Middle Aged
Prospective Studies
Pulmonary Edema / immunology
Respiratory Distress Syndrome, Adult / etiology,  immunology*
Shock, Septic / complications*
Shock, Traumatic / complications*

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