| Pathophysiologic mechanisms of calcific aortic stenosis. | |
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MedLine Citation:
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PMID: 22361851 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Calcific aortic stenosis (CAS) comprises the leading indication for valve replacement in the Western world. Until recently, progressive calcification was considered to be a passive process. Emerging evidence, however, suggests that degenerative aortic stenosis constitutes an active process involving stimulation of several pathophysiologic pathways such as inflammation and osteogenesis. In addition, CAS and atherosclerosis share common features regarding histopathology of lesions. These novel data raise a new perspective on the prevention and treatment of disease. The current article reviews the most important pathophysiologic mechanisms of senile aortic stenosis. |
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Authors:
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Alexandros Alexopoulos; Andreas Kaoukis; Helen Papadaki; Vlassios Pyrgakis |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-23 |
Journal Detail:
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Title: Therapeutic advances in cardiovascular disease Volume: - ISSN: 1753-9455 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101316343 Medline TA: Ther Adv Cardiovasc Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Cardiology, Athens General Hospital, Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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