Document Detail


Pathophysiologic mechanisms of calcific aortic stenosis.
MedLine Citation:
PMID:  22361851     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Calcific aortic stenosis (CAS) comprises the leading indication for valve replacement in the Western world. Until recently, progressive calcification was considered to be a passive process. Emerging evidence, however, suggests that degenerative aortic stenosis constitutes an active process involving stimulation of several pathophysiologic pathways such as inflammation and osteogenesis. In addition, CAS and atherosclerosis share common features regarding histopathology of lesions. These novel data raise a new perspective on the prevention and treatment of disease. The current article reviews the most important pathophysiologic mechanisms of senile aortic stenosis.
Authors:
Alexandros Alexopoulos; Andreas Kaoukis; Helen Papadaki; Vlassios Pyrgakis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-23
Journal Detail:
Title:  Therapeutic advances in cardiovascular disease     Volume:  -     ISSN:  1753-9455     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101316343     Medline TA:  Ther Adv Cardiovasc Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiology, Athens General Hospital, Athens, Greece.
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