| Pathophysiologic mechanisms of allergic and pseudo-allergic reactions to foods, food additives and drugs. | |
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MedLine Citation:
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PMID: 6391287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Allergic or pseudo-allergic reactions elicited by per os intake of foods, food additives or drugs may be based on one or several of the following immunopathologic mechanisms: 1) specific IgE bound to mast cells and/or basophils; 2) antigen-IgE soluble complexes hitting various target cells; 3) antigen-IgG complexes generating anaphylatoxins; 4) generation of anaphylatoxins by alternate pathway complement activation; 5) release of mast cell mediators by other direct triggering mechanisms (e.g., basic peptides, peptones); 6) effects on other target cells such as neutrophils and platelets; 7) reactions mediated by specific effector lymphocytes. While allergic reactions in a classical sense involve a sensitization process leading to the formation of specific immunologic agents such as antibodies or specific T lymphocytes, pseudo-allergic reactions appear to involve the same inflammatory mediators which are formed and/or released through different mechanisms and without the necessity for specific sensitization. The complexity of the phenomena possibly involved continues to create great difficulties in the objective diagnosis of food allergy. |
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Authors:
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A L de Weck |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of allergy Volume: 53 ISSN: 0003-4738 ISO Abbreviation: Ann Allergy Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-01-18 Completed Date: 1985-01-18 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372346 Medline TA: Ann Allergy Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 583-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaphylatoxins
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immunology Animals Antigen-Antibody Complex / immunology Antigens / immunology Basophils / immunology Blood Platelets / immunology Complement C3 / immunology Complement C3a Complement C5 / immunology Complement C5a Drug Hypersensitivity / immunology* Food Additives / adverse effects* Food Hypersensitivity / immunology* Granulocytes / immunology Histamine / immunology Humans Immunoglobulin E / immunology Immunoglobulin G / immunology Mast Cells / immunology Narcotics / immunology T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Anaphylatoxins; 0/Antigen-Antibody Complex; 0/Antigens; 0/Complement C3; 0/Complement C5; 0/Food Additives; 0/Immunoglobulin G; 0/Narcotics; 37341-29-0/Immunoglobulin E; 51-45-6/Histamine; 80295-42-7/Complement C3a; 80295-54-1/Complement C5a |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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