| Pathomorphology of myocardial circulation: comparative study in increased left or right ventricle afterload. | |
| | |
MedLine Citation:
|
PMID: 19039949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Comparative study of pathomorphology of myocardial circulation under conditions of increased afterload of the left or right ventricles showed similar changes. All compartments of the coronary bed were plethoric, capillary blood stasis and perivascular edema, more pronounced in arterial vessels, were detected in both cases. These changes equally involved both ventricles and the ventricular septum. Significant differences consisted in local increase in the density of functioning capillaries. The increase was the maximum in hemodynamically overloaded ventricle and ventricular septum, presumably due to increase of their contractile activity. The density of functioning capillaries in the intact (vs. pressure overloaded) ventricle also increased, but to a lesser degree, which could be due to systemic neurohumoral effects. If increased afterload was complicated by the development of heart failure, circulatory disorders in the myocardium progressed. Significant increase in the density of functioning capillaries in all cardiac compartments indicated decreased vascular tone and exhaustion of coronary reserve. This was paralleled by a sharp arterial plethora in case of increased afterload of the left ventricle and sharp blood stasis in the microcirculatory bed in case of increased right ventricle afterload. Reduction of effective perfusion pressure in the presence of coronary dystonia can cause coronary insufficiency and myocardial ischemia in case of increased right ventricle afterload. |
| | |
Authors:
|
M S Tverskaya; V V Sukhoparova; V V Karpova; A P Raksha; M K Kadyrova; N Z Abdulkerimova; N A Bobrova |
Related Documents
:
|
2240259 - Circulatory effects of endothelin in newborn piglets. 3840319 - Neuropeptide y and sympathetic control of heart contractility and coronary vascular tone. 9633919 - Ineffective perfusion-contraction matching in conscious, chronically instrumented pigs ... 21080979 - Usefulness of ambulatory blood pressure monitoring and head-up tilt test in the evaluat... 12626969 - Leukotriene-mediated coronary vasoconstriction and loss of myocardial contractility evo... 1904029 - Rebound myocardial ischaemia following abrupt interruption of intravenous nitroglycerin... 17408259 - Pressure-induced phase transitions in pbtio3: a query for the polarization rotation the... 4042549 - Beta-adrenoceptor responsiveness and plasma catecholamines as determinants of cardiovas... 1012109 - Increased oxygen pressure to improve the efficiency of membrane oxygenators. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Bulletin of experimental biology and medicine Volume: 145 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2008 Mar |
Date Detail:
|
Created Date: 2008-12-01 Completed Date: 2009-01-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
|
Languages: eng Pagination: 377-81 Citation Subset: IM |
Affiliation:
|
Russian State Medical University, Federal Agency for Health Care and Social Development, Moscow. mtver@rsmu.ru |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aortic Valve Stenosis / pathology Coronary Circulation* Coronary Vessels / pathology, physiopathology Guinea Pigs Heart Ventricles / pathology* Pulmonary Valve Stenosis / pathology Ventricular Function, Left / physiology* Ventricular Function, Right / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultrastructure of connective tissue of eye drainage system in ophthalmic hypertension associated wit...
Next Document: Evaluation of erythrocyte shape and status by laser interference microscopy.