Document Detail


Pathomorphological characteristics of experimental toxemia induced by thermostable Yersinia pseudotuberculosis toxin.
MedLine Citation:
PMID:  11182834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pathogenic properties of thermostable toxin responsible for pathogenicity of Yersinia pseudotuberculosis were experimentally studied. The toxin exerted a pronounced polyorgan cytopathogenic effect with predominating degenerative destructive changes and membranolytic effect on cell ultrastructure of parenchymatous organs. The toxin is believed to be directly involved in the development of typical pathomorphological picture of pseudotuberculosis, which confirms its pathogenetic role.
Authors:
L M Isachkova; N F Timchenko; E P Nedashkovskaya; S D Raznik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  130     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-09-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1123-6     Citation Subset:  IM    
Affiliation:
Institute of Epidemiology and Microbiology, Siberian Division, Russian Academy of Medical Sciences, Vladivostok, Russia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Toxins / administration & dosage,  toxicity*
Capillaries / drug effects,  pathology
Disease Models, Animal
Enterotoxins / administration & dosage,  toxicity*
Gallbladder / drug effects,  pathology
Heart / drug effects
Kidney / drug effects,  pathology
Liver / drug effects,  pathology
Lung / drug effects,  pathology
Mice
Myocardium / pathology
Spleen / drug effects,  pathology
Toxemia / pathology*
Yersinia pseudotuberculosis*
Chemical
Reg. No./Substance:
0/Bacterial Toxins; 0/Enterotoxins; 0/heat-stable enterotoxin (Yersinia)

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