Document Detail

Pathomorphological changes in experimentally induced canine myocardial infarction.
MedLine Citation:
PMID:  3356076     Owner:  NLM     Status:  MEDLINE    
We performed a pathological study of experimental canine myocardial infarction (MI) induced by coronary thrombosis which was made by endothelial denudation and induction of luminal stenosis in 20 dogs (Group I). Another model of experimental MI by coronary ligation was also evaluated in Groups II and III. Thirteen dogs of Group I and 7 of Group II underwent persistent coronary occlusion for 6-8 h (Group IA and Group IIA), and 7 of Group I and 7 of Group II underwent coronary reperfusion with intravenous urokinase (UK) (20,000 IU/kg) in Group IB for 5 h following temporary coronary occlusion for 3 h (Groups IB and IIB). The remaining 5 dogs underwent coronary reperfusion for 5 h following intravenous 20,000 IU/kg UK after 3 h ligation. Microscopically, myocardial hemorrhage was present in 6 (86%) Group IB, 4 (31%) Group IA and in no Group IIA dogs (p less than .025 and p less than .005 vs. IB). Four Group IIB and 3 Group III dogs also showed myocardial hemorrhage. Moderate hemorrhage was present only in Group I and slight hemorrhage was frequently observed in reperfused hearts. Contraction band necrosis (CBN) was present in 8 (62%) Group IA, all Group IB, all Group IIB, and 4 (80%) Group III dogs. However, there was no hemorrhage with CBN in Group IIA (p less than .005 vs. IIB). Marked CBN was present only in Group I.(ABSTRACT TRUNCATED AT 250 WORDS)
T Tomaru; Y Uchida; T Sugimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  11     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-05-13     Completed Date:  1988-05-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  149-57     Citation Subset:  IM    
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Coronary Circulation / drug effects
Coronary Disease / pathology*
Coronary Thrombosis / pathology*
Disease Models, Animal
Hemorrhage / pathology
Heparin / administration & dosage
Infusions, Intravenous
Myocardial Infarction / pathology*
Myocardium / pathology*
Urokinase-Type Plasminogen Activator / administration & dosage
Reg. No./Substance:
9005-49-6/Heparin; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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