| Pathomorphological changes in experimentally induced canine myocardial infarction. | |
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MedLine Citation:
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PMID: 3356076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed a pathological study of experimental canine myocardial infarction (MI) induced by coronary thrombosis which was made by endothelial denudation and induction of luminal stenosis in 20 dogs (Group I). Another model of experimental MI by coronary ligation was also evaluated in Groups II and III. Thirteen dogs of Group I and 7 of Group II underwent persistent coronary occlusion for 6-8 h (Group IA and Group IIA), and 7 of Group I and 7 of Group II underwent coronary reperfusion with intravenous urokinase (UK) (20,000 IU/kg) in Group IB for 5 h following temporary coronary occlusion for 3 h (Groups IB and IIB). The remaining 5 dogs underwent coronary reperfusion for 5 h following intravenous 20,000 IU/kg UK after 3 h ligation. Microscopically, myocardial hemorrhage was present in 6 (86%) Group IB, 4 (31%) Group IA and in no Group IIA dogs (p less than .025 and p less than .005 vs. IB). Four Group IIB and 3 Group III dogs also showed myocardial hemorrhage. Moderate hemorrhage was present only in Group I and slight hemorrhage was frequently observed in reperfused hearts. Contraction band necrosis (CBN) was present in 8 (62%) Group IA, all Group IB, all Group IIB, and 4 (80%) Group III dogs. However, there was no hemorrhage with CBN in Group IIA (p less than .005 vs. IIB). Marked CBN was present only in Group I.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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T Tomaru; Y Uchida; T Sugimoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 11 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-05-13 Completed Date: 1988-05-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 149-57 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / drug effects Coronary Disease / pathology* Coronary Thrombosis / pathology* Disease Models, Animal Dogs Electrocardiography Hemorrhage / pathology Heparin / administration & dosage Infusions, Intravenous Myocardial Infarction / pathology* Myocardium / pathology* Necrosis Urokinase-Type Plasminogen Activator / administration & dosage |
| Chemical | |
Reg. No./Substance:
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9005-49-6/Heparin; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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