Document Detail

Pathology of the unstable plaque.
MedLine Citation:
PMID:  12024333     Owner:  NLM     Status:  MEDLINE    
The term "vulnerable" in the context of human coronary plaques was originally intended to provide a morphological description consistent with lesions prone to rupture. Coronary thrombosis is now recognized as a diverse process arising from plaque rupture, erosion, or calcified nodules. These findings have prompted the search for more definitive terminology to describe the precursor lesion of rupture, now referred to as "thin-cap fibroatheromas." This review provides a focused discussion of the thin-cap fibroatheroma as a specific cause of acute coronary syndromes. The pathology of the unstable plaque is presented in reference to unstable angina, acute myocardial infarction, and sudden coronary death. The influence of risk factors for coronary artery disease on culprit lesion morphology is also discussed. Finally, the value of coronary calcification, as a predictor of unstable plaques in the clinical setting, is explored.
Renu Virmani; Allen P Burke; Andrew Farb; Frank D Kolodgie
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  44     ISSN:  0033-0620     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-05-23     Completed Date:  2002-06-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  349-56     Citation Subset:  AIM; IM    
Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
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MeSH Terms
Angina Pectoris / etiology,  pathology
Angina, Unstable / etiology,  pathology
Calcinosis / complications,  pathology
Coronary Artery Disease / complications,  pathology*
Coronary Thrombosis / etiology,  pathology
Death, Sudden, Cardiac / etiology,  pathology
Myocardial Infarction / etiology,  pathology
Risk Factors
Rupture, Spontaneous / etiology,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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