| Pathology of the thyroid in severe acute respiratory syndrome. | |
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MedLine Citation:
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PMID: 16996569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The severe acute respiratory syndrome (SARS) epidemic started in November 2002 and spread worldwide. The pathological changes in several human organs of patients with SARS have been extensively described. However, to date, little has been reported about the effects of this infection on the thyroid gland. Femoral head necrosis and low serum triiodothyronine and thyroxine levels, commonly found in patients with SARS, raise the possibility of thyroid dysfunction. We have undertaken this study to evaluate for any potential injury to the thyroid gland caused by SARS on tissue samples obtained from 5 SARS autopsies. The terminal deoxynucleotidyl transferase-mediated dUPT nick end-labeling assay was performed to identify apoptotic cells. The follicular epithelium was found to be damaged with large numbers of cells exfoliated into the follicle. The terminal deoxynucleotidyl transferase-mediated dUPT nick end-labeling assay demonstrated many cells undergoing apoptosis. Follicular architecture was altered and showed distortion, dilatation, and collapse. No distinct calcitonin-positive cells were detectable in the SARS thyroids. In conclusion, both parafollicular and follicular cells were injured. This may provide an explanation both for low serum triiodothyronine and thyroxine levels and the osteonecrosis of the femoral head associated with patients with SARS. Apoptosis may play a role in the pathogenesis of SARS associated coronavirus infection in the thyroid gland. |
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Authors:
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Lan Wei; Shen Sun; Cai-Hong Xu; Jing Zhang; Yun Xu; Hong Zhu; Suat-Cheng Peh; Christine Korteweg; Michael A McNutt; Jiang Gu |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-25 |
Journal Detail:
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Title: Human pathology Volume: 38 ISSN: 0046-8177 ISO Abbreviation: Hum. Pathol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-15 Completed Date: 2007-02-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421547 Medline TA: Hum Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 95-102 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking (Beijing) University, 100083 Beijing, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apoptosis / physiology Autopsy Calcitonin / analysis Fatal Outcome Female Humans Immunohistochemistry In Situ Nick-End Labeling Male Middle Aged Severe Acute Respiratory Syndrome / complications* Thyroid Diseases / etiology, pathology*, physiopathology Thyroid Gland / chemistry, pathology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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