| Pathology of soft tissue sarcomas. | |
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MedLine Citation:
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PMID: 19734027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sarcomas are a rare, complex group of childhood and adult neoplasms with differentiation towards mesenchymal tissue, which may arise almost anywhere in the body. Although pathologically diverse, they frequently exhibit similar clinical presentations and radiological features. Correct histopathological diagnosis is therefore crucial, but there is overlap between histological patterns of malignant tumours, between benign and malignant lesions, and with non-mesenchymal tumours. Immunohistochemistry and molecular genetic techniques, the latter to detect tumour-specific alterations, add significantly to histological interpretation, but several groups of tumours still lack reliable immunohistochemical markers or reproducible genetic changes. The classification of sarcomas is incomplete and continues to evolve, and although the biology of many remains relatively poorly understood, our increasing insight into molecular events occurring in these tumours is certain to aid future diagnosis and therapy. This paper aims to give a broad overview of several of the main soft tissue sarcomas from a clinicopathological perspective, discussing laboratory diagnosis and the use and limitations of ancillary investigations, including recent developments in molecular diagnosis. |
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Authors:
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K Thway |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-09-06 |
Journal Detail:
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Title: Clinical oncology (Royal College of Radiologists (Great Britain)) Volume: 21 ISSN: 1433-2981 ISO Abbreviation: Clin Oncol (R Coll Radiol) Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2010-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002902 Medline TA: Clin Oncol (R Coll Radiol) Country: England |
Other Details:
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Languages: eng Pagination: 695-705 Citation Subset: IM |
Affiliation:
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Department of Histopathology, Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK. khin.thway@rmh.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gene Expression Profiling
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methods Gene Expression Regulation, Neoplastic Humans Immunohistochemistry / methods Mutation Oligonucleotide Array Sequence Analysis / methods Sarcoma / classification, genetics, pathology* Soft Tissue Neoplasms / classification, genetics, pathology* Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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