Document Detail

Pathology of the liver, kidney and gonad of flounder (Platichthys flesus) from a UK estuary impacted by endocrine disrupting chemicals.
MedLine Citation:
PMID:  11460705     Owner:  NLM     Status:  MEDLINE    
The Mersey estuary is highly contaminated with xenobiotics compared to the nearby Dee estuary. Male flounder, a migratory flatfish caught in the Mersey frequently contains high blood concentrations of the oestrogen controlled, female protein vitellogenin, suggesting that Mersey flounder have been exposed to endocrine disrupting contaminants. Males caught from the Dee contain lower blood vitellogenin levels. Preliminary histopathological examination of 410 flounder from both estuaries, focuses on the liver, kidney and gonads. Hepatic tubular vacuolation, foci of cellular alteration, and hepatocellular tumours were seen. Renal and gonadal pathology included the presence of two Mersey fish with enlarged and abnormal glomeruli, three phenotypic male Mersey flounder with unilateral intersex gonads and one male with bilateral, abnormal ovarian follicular components in the testis. These initial results provide pathological evidence of xenobiotic exposure in flounder sampled from both estuaries. Preliminary findings from flounder sampled from Millport, an offshore site in Southwest Scotland, showed no histopathological evidence of xenobiotic exposure.
M G Simpson; M Parry; A Kleinkauf; D Swarbreck; P Walker; R T Leah
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Marine environmental research     Volume:  50     ISSN:  0141-1136     ISO Abbreviation:  Mar. Environ. Res.     Publication Date:    2000 Jul-Dec
Date Detail:
Created Date:  2001-07-19     Completed Date:  2001-08-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9882895     Medline TA:  Mar Environ Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
Centre for Marine and Coastal Studies, University of Liverpool, Birkenhead, L41 9HP, UK.
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MeSH Terms
Great Britain
Kidney / pathology*
Liver / pathology*
Ovary / pathology*
Sex Differentiation / drug effects
Testis / pathology*
Vitellogenins / metabolism
Water Pollutants, Chemical / toxicity*
Xenobiotics / toxicity
Reg. No./Substance:
0/Vitellogenins; 0/Water Pollutants, Chemical; 0/Xenobiotics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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