| Pathology of hepatic iron overload. | |
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MedLine Citation:
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PMID: 17729397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although progress in imaging and genetics allow for a noninvasive diagnosis of most cases of genetic iron overload, liver pathology remains often useful (1) to assess prognosis by grading fibrosis and seeking for associated lesions and (2) to guide the etiological diagnosis, especially when no molecular marker is available. Then, the type of liver siderosis (parenchymal, mesenchymal or mixed) and its distribution throughout the lobule and the liver are useful means for suggesting its etiology: HLA-linked hemochromatosis gene (HFE) hemochromatosis or other rare genetic hemochromatosis, nonhemochromatotic genetic iron overload (ferroportin disease, aceruloplasminemia), or iron overload secondary to excessive iron supply, inflammatory syndrome, noncirrhotic chronic liver diseases including dysmetabolic iron overload syndrome, cirrhosis, and blood disorders. |
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Authors:
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Yves Deugnier; Bruno Turlin |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 13 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-30 Completed Date: 2007-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 4755-60 Citation Subset: IM |
Affiliation:
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Liver Unit and CIC INSERM 0203, Pontchaillou University Hospital, Rennes 35033, France. yves.deugnier@univ-rennes1.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Histocompatibility Antigens Class I
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genetics Humans Iron Overload / diagnosis, etiology*, pathology* Liver / metabolism, pathology* Liver Cirrhosis / metabolism, pathology Liver Diseases / complications Membrane Proteins / genetics Mutation / genetics |
| Chemical | |
Reg. No./Substance:
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0/HFE protein, human; 0/Histocompatibility Antigens Class I; 0/Membrane Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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