Document Detail

Pathology of experimental CV777 coronavirus enteritis in piglets. I. Histological and histochemical study.
MedLine Citation:
PMID:  6280359     Owner:  NLM     Status:  MEDLINE    
Sixteen cesarean-derived colostrum-deprived piglets were infected oronasally with CV777 coronavirus on the second or third day of life. Two uninfected piglets were controls. They were killed at 96 and 120 hours after birth. After an incubation period of 22 to 36 hours, all principals showed severe diarrhea. The principals were killed between 12 and 120 hours after infection. Exfoliation of enterocytes were seen first in the piglet killed 24 hours after infection (two hours after the diarrhea began). From that time on, shortening and fusion of villi was present in all small intestinal parts. Affected cells showed vacuolation. The histochemical study showed that infected piglets had decreased activity of all four enzymes studied. The light microscope showed no lesions in the absorptive colonic epithelium. The significance of the lesions in relation to intestinal dysfunction is discussed, and lesions are compared to those of transmissible gastroenteritis and porcine rotavirus infection.
W Coussement; R Ducatelle; P Debouck; J Hoorens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary pathology     Volume:  19     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  46-56     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn*
Coronaviridae Infections / complications,  pathology,  veterinary*
Diarrhea / etiology,  veterinary
Enteritis / complications,  pathology,  veterinary*
Epithelium / ultrastructure
Swine Diseases / pathology*
Vacuoles / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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