Document Detail

Pathology of congenital syphilis in rabbits.
MedLine Citation:
PMID:  8406873     Owner:  NLM     Status:  MEDLINE    
We have developed a model for congenital syphilis in the rabbit. This report provides additional information on newborn tissue pathology in animals that were infected in utero. A total of 35 pregnancies were evaluated, each containing 6 to 12 newborns. In the infected group, the mortality was approximately 50%; of the live newborns, half appeared normal and half were hyperreflexic, weak, and runty. Gross pathology in the sickly newborns was quite prevalent and involved enlarged spleens with isolated spots of necrosis; enlarged livers that were overtly congested and hemorrhagic and had numerous granular, white spots; and brains with hemorrhage in the occipital area. Histopathology was apparent in different tissues. Lymphocytes, plasma cells, and vacuolated macrophages were prominent in livers, spleens, brains, and bones. A few actively motile treponemes were visualized by dark-field microscopy within extracts of spleen and within cerebrospinal fluid. Low numbers of treponemes were also demonstrated in sections of brain and liver by using the Warthin-Starry silver stain technique. Blood hematocrits were decreased, and extramedullary hematopoiesis was prominent within spleens and livers; this is consistent with anemia. This rabbit model exhibits many of the same pathologic features commonly found in human congenital syphilis.
M K Froberg; T J Fitzgerald; T R Hamilton; B Hamilton; M Zarabi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  61     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1993-11-24     Completed Date:  1993-11-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4743-9     Citation Subset:  IM    
Department of Medical Microbiology and Immunology, School of Medicine, University of Minnesota, Duluth 55812.
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MeSH Terms
Animals, Newborn
Brain / pathology
Disease Models, Animal
Liver / pathology
Spleen / pathology
Syphilis, Congenital / mortality,  pathology*
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