Document Detail

Pathology of the cerebral artery in Binswanger's disease in the aged: observation by serial sections and morphometry of the cerebral arteries.
MedLine Citation:
PMID:  15068169     Owner:  NLM     Status:  MEDLINE    
Binswanger's disease (BD) is not rare in the aged. The aim of the present study was to compare the etiopathogenesis of BD of the aged (aged-BD) with that of classic-BD, with the aid of morphometry of the arterial medial thickness and reconstruction of the cerebral medullary arteries using serial sections from five autopsy cases. The age range of the aged-BD cases was 73-89 years. The mean heart weight of these cases was 296 g, in contrast to 391 g of the five age-matched cases of hypertension without diffuse myelin loss and atrophy of the cerebral white matter (HT). Although significant medial hypertrophy of the subarachnoid and medullary arteries was not found in all aged-BD cases, differently from classic-BD, all five cases of aged-BD commonly presented significantly widespread loss of the medial smooth muscle cells (SMC) of the medullary arteries as compared with HT, similar to the case in classic-BD. The etiopathogenesis of aged-BD is common to that of classic-BD; stiffening caused by hypertensive changes of the medullary artery, especially SMC loss, is responsible for the diffuse myelin loss and atrophy of the cerebral white matter of BD, rather than grade of hypertension itself or hypertensive medial hypertrophy. As the mechanism of such an especially severe involvement of the cerebral medullary artery in BD, some genetic abnormality in the functional response or vulnerability to hypertension of the artery should be considered.
Riki Okeda; Shigeo Murayama; Motoji Sawabe; Toshihiko Kuroiwa
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Neuropathology : official journal of the Japanese Society of Neuropathology     Volume:  24     ISSN:  0919-6544     ISO Abbreviation:  Neuropathology     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-07     Completed Date:  2004-05-10     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9606526     Medline TA:  Neuropathology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  21-9     Citation Subset:  IM    
Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Aging / pathology*
Cerebral Arteries / pathology*
Dementia, Vascular / pathology*

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