| Pathology of Shy-Drager syndrome. | |
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MedLine Citation:
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PMID: 448397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In four patients with the Shy-Drager syndrome, detailed pathological findings in the central nervous system are described. All four patients had striatonigral degeneration, olivopontocerebellar atrophy, pyramidal tract degeneration and ventral horn cell loss. Along with the multisystem degeneration, there was widespread loss of thoracolumbar autonomic neurons, which was demonstrated by comparative cell counts of the intermediolateral horns in two of the four patients. In all four patients, autonomic nuclei of the sacral cord, particularly the Onuf's and intermediolateral nuclei, were severely affected and diffuse cell loss in the nuclei seems to account for disordered bladder, rectal and sexual functions in Shy-Drager syndrome. |
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Authors:
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J H Sung; A R Mastri; E Segal |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neuropathology and experimental neurology Volume: 38 ISSN: 0022-3069 ISO Abbreviation: J. Neuropathol. Exp. Neurol. Publication Date: 1979 Jul |
Date Detail:
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Created Date: 1979-08-29 Completed Date: 1979-08-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985192R Medline TA: J Neuropathol Exp Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 353-68 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Corpus Striatum / pathology Female Globus Pallidus / pathology Humans Hypotension, Orthostatic / pathology* Male Middle Aged Nervous System Diseases / pathology* Putamen / pathology Substantia Nigra / pathology Syndrome |
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