| Pathology of MEN-1: morphology, clinicopathologic correlations and tumour development. | |
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MedLine Citation:
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PMID: 9681843 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple endocrine neoplasia type 1 (MEN-1) is an inherited syndrome which is characterized by the occurrence of neoplastic lesions in the parathyroids, the pancreas, duodenum, anterior pituitary and, less commonly, also in the stomach, thymus and lung. Its genetic defect has recently been identified and appears to involve a new type of tumour suppressor gene called mu on chromosome 11q13. In this overview, we will summarize the morphological features of the MEN-1 phenotype, discuss its clinicopathologic profile and prognosis and outline the recent findings on the molecular pathology of this syndrome. |
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Authors:
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P Komminoth; P U Heitz; G Klöppel |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of internal medicine Volume: 243 ISSN: 0954-6820 ISO Abbreviation: J. Intern. Med. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-08-13 Completed Date: 1998-08-13 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 455-64 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Zürich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diagnosis, Differential Humans Multiple Endocrine Neoplasia Type 1 / diagnosis*, genetics*, pathology Prognosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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