Document Detail

Pathology consultation on anticoagulation monitoring: factor X-related assays.
MedLine Citation:
PMID:  24124140     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To review various anticoagulation therapies and related laboratory monitoring issues, with a focus on factor X-related chromogenic assays.
METHODS: A case-based approach is used to review pertinent published literatures and product inserts of anticoagulation drugs and to look back on clinical use of factor X-related chromogenic assays.
RESULTS: The number of anticoagulants available to clinicians has increased greatly in the past decade. Whether and how these anticoagulants should be monitored are areas of uncertainty for clinicians, which can lead to misuse of laboratory assays and suboptimal patient management. Factor X-related assays are of particular concern because of the similar and often confusing test names. Based on a common clinical case scenario and literature review regarding anticoagulant monitoring, an up-to-date discussion and review of the various factor X-related assays are provided, focusing on the differences in test designs and clinical utilities between the chromogenic anti-Xa and chromogenic factor X activity assays.
CONCLUSIONS: Anticoagulation therapy and related laboratory monitoring are rapidly evolving areas of clinical practices. A good knowledge of relevant laboratory assays and their clinical applications is necessary to help optimize patient care.
Geoffrey D Wool; Chuanyi M Lu;
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  140     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-14     Completed Date:  2013-12-05     Revised Date:  2014-07-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  623-34     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Anticoagulants / therapeutic use*
Biological Assay
Biological Markers / blood
Blood Coagulation Tests
Drug Monitoring / methods*
Drug Overdose / prevention & control
Factor Xa / antagonists & inhibitors,  metabolism*
Hemorrhage / blood,  drug therapy*
Infusions, Intravenous
Laboratories, Hospital
Middle Aged
Pathology, Surgical / methods*
Referral and Consultation*
Reg. No./Substance:
0/Anticoagulants; 0/Biological Markers; EC Xa
Erratum In:
Am J Clin Pathol. 2013 Jun;141(6):899

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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