Document Detail

Pathology of 2-alkyl and 2-hydroxy naphthoquinone toxicity in rats.
MedLine Citation:
PMID:  21812748     Owner:  NLM     Status:  In-Data-Review    
Abstract Extract The oral administration of 2-methyl-1, 4-naphthoquinone (menadione) to rats caused oxidative destruction of the erythrocyte. Heinz body formation occurred in erythrocytes, lowered PCVs and haemoglobin Occurred in blood, with splenic and hepatic erythroclasis, and iron conservation in the spleen, liver and kidney. These effects diminished when increasingly large alkyl substitutions of the methyl group of thi naphthoquinone were made. No effect was caused by the 2-decyl derivative.
B L Smith; R Munday
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  New Zealand veterinary journal     Volume:  43     ISSN:  0048-0169     ISO Abbreviation:  N Z Vet J     Publication Date:  1995 Jan 
Date Detail:
Created Date:  2011-08-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0021406     Medline TA:  N Z Vet J     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  124     Citation Subset:  -    
a Toxicology and Food Safety Research Group, AgResearch , Ruakura Research Centre , Hamilton , New Zealand.
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