| Pathological subthalamic nucleus oscillations in PD: can they be the cause of bradykinesia and akinesia? | |
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MedLine Citation:
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PMID: 19460368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is growing evidence that Parkinson's disease (PD) is associated with pathological synchronous oscillatory activity in the basal ganglia. These synchronized oscillations primarily occur in the 11-30 Hz range, the so-called beta band. Studies of local field potential activity in the subthalamic nucleus (STN) of PD patients suggest that exaggerated beta band oscillatory activity can disrupt function and, in particular, may contribute to slowness of movement. It has been previously shown that the degree of beta oscillatory activity in the STN of PD patients correlates with the patients' benefit from dopaminergic medications, but not with baseline motor deficits. In a paper that was recently published in Experimental Neurology, [Kuhn A.A., Tsui A., Aziz T., Ray N., Brucke C., Kupsch A., Schneider G.H., Brown P., 2009. Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity. Exp. Neurol. 215, 380-387.] the authors further establish that the degree of suppression of beta oscillations in the STN by dopaminergic medications can predict the level of improvement in bradykinesia and rigidity but not tremor. This commentary reviews some of the recent findings on beta oscillatory activity in PD and highlights the possible role of these pathological oscillations in mediating PD symptoms. |
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Authors:
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Moran Weinberger; William D Hutchison; Jonathan O Dostrovsky |
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Publication Detail:
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Type: Comment; Journal Article; Review Date: 2009-05-19 |
Journal Detail:
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Title: Experimental neurology Volume: 219 ISSN: 1090-2430 ISO Abbreviation: Exp. Neurol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-18 Completed Date: 2009-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 58-61 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Toronto, Toronto, ON, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects,
physiology Akinetic Mutism / drug therapy, physiopathology Antiparkinson Agents / pharmacology Biological Clocks / drug effects, physiology* Dopamine Agents / pharmacology Humans Hypokinesia / drug therapy, physiopathology Parkinson Disease / drug therapy, physiopathology* Subthalamic Nucleus / anatomy & histology, physiopathology* Synaptic Transmission / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Dopamine Agents |
| Comments/Corrections | |
Comment On:
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Exp Neurol. 2009 Feb;215(2):380-7
[PMID:
19070616
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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