| Pathological study of postcoronary arteritis in adolescents and young adults: with reference to the relationship between sequelae of Kawasaki disease and atherosclerosis. | |
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MedLine Citation:
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PMID: 11178671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify whether the cardiac sequelae of Kawasaki disease (KD), postcoronary arteritis lesions can become a risk factor for atherosclerosis of the coronary arteries, six autopsy cases of patients older than 15 years of age with coronary arterial lesions caused by arteritis in childhood were examined histologically. Twenty-four arteries were inspected: 10 had no evidence of aneurysm formation, 7 arteries manifested simple dilatation of the lumen, and in 7 arteries there were aneurysms with recanalization. In the group in which there were no aneurysms, "new intimal thickening" was observed in addition to the preexisting intimal thickening which had been caused by arteritis in the acute phase of KD. In the second group with aneurysmal arteries whose lumen remained dilated, thrombotic occlusion occurred in 4 of 6 aneurysms. In addition, advanced atherosclerotic changes (i.e., complicated lesions) were found in a 39-year-old patient. Finally, in the third group of arteries which manifested recanalized lumens after thrombotic occlusion of the aneurysms, new intimal thickening was seen on the internal side and some of them were occluded. The findings in this study suggest that aneurysms present in coronary arteries in individuals with a history of KD constitute a risk factor for atherosclerosis later in life. |
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Authors:
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K Takahashi; T Oharaseki; S Naoe |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric cardiology Volume: 22 ISSN: 0172-0643 ISO Abbreviation: Pediatr Cardiol Publication Date: 2001 Mar-Apr |
Date Detail:
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Created Date: 2001-03-12 Completed Date: 2001-05-03 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 138-42 Citation Subset: IM |
Affiliation:
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Department of Pathology, Ohashi Hospital, Toho University School of Medicine, Meguro, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Arteritis / pathology* Coronary Artery Disease / pathology* Coronary Vessels / pathology* Female Humans Male Mucocutaneous Lymph Node Syndrome / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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