Document Detail

Pathological role of aquaporin-2 in impaired water excretion and hyponatremia.
MedLine Citation:
PMID:  15089964     Owner:  NLM     Status:  MEDLINE    
In the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), inappropriately elevated secretion of vasopressin can result in a reduction of antidiuretic efficacy: a phenomenon known as 'vasopressin escape'. We compared experimental SIADH with 1-deamino-8-d-arginine vasopressin (dDAVP)-excess rats, where both groups received continuous subcutaneous administration of dDAVP by osmotic minipump but the SIADH rats also received a liquid diet that induced hyponatraemia. The SIADH rats, but not the dDAVP excess rats, showed a marked attenuation of urinary concentrating ability. Vasopressin V(2) receptor binding capacity and mRNA expression were similar between the two groups, but the SIADH rats showed a diminished up-regulation of aquaporin-2 (AQP-2) mRNA and protein expression. These findings indicate the presence of tonicity-response regions in the AQP-2 promoter gene, and that either hypervolemia or hypotonicity may attenuate the postreceptor signalling of vasopressin in renal collecting duct cells in SIADH rats.
S Ishikawa; T Saito; K Kasono
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  16     ISSN:  0953-8194     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  293-6     Citation Subset:  IM    
Department of Medicine, Jichi Medical School Omiya Medical Center, Saitama, Japan.
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MeSH Terms
Aquaporin 2
Aquaporins / genetics*,  metabolism*
Hyponatremia / metabolism*
Inappropriate ADH Syndrome / metabolism*
Kidney Tubules, Collecting / metabolism
Water / metabolism
Water-Electrolyte Balance / physiology*
Reg. No./Substance:
0/Aqp2 protein, rat; 0/Aquaporin 2; 0/Aquaporins; 7732-18-5/Water

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