Pathological and molecular biological aspects of the renal epithelial neoplasms, up-to-date.

Pathological and molecular biological aspects of the renal epithelial neoplasms, up-to-date.

MedLine Citation:	PMID: 15144395 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	Renal neoplasms are not necessarily high in frequency, but they are characteristic in their heterogeneity and occasional association with systemic familial tumor syndromes and phacomatoses (e.g. clear cell renal cell carcinoma and von Hippel-Lindau disease, Wilms tumor and aniridia, genitourinary malformation and mental retardation (so-called, WAGR syndrome), and angiomyolipoma and tuberous sclerosis). Physicians and pathologists should take note of these syndromes and associated renal neoplasms because they have provided important clues to elucidate the mechanism of tumorigenesis concerning cancer-suppressor genes. This review aims to present recent classification of renal parenchymal neoplasms based on their molecular biological characteristics, and future problems yet to be clarified.

Authors:	Yoji Nagashima; Yoshiaki Inayama; Yasumasa Kato; Naoki Sakai; Hiroshi Kanno; Ichiro Aoki; Masahiro Yao
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Publication Detail:	Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Journal Detail:	Title: Pathology international Volume: 54 ISSN: 1320-5463 ISO Abbreviation: Pathol. Int. Publication Date: 2004 Jun
Date Detail:	Created Date: 2004-05-17 Completed Date: 2004-12-07 Revised Date: 2006-11-15
Medline Journal Info:	Nlm Unique ID: 9431380 Medline TA: Pathol Int Country: Australia
Other Details:	Languages: eng Pagination: 377-86 Citation Subset: IM
Affiliation:	Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan. ynagas@med.yokohama-cu.ac.jp
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MeSH Terms
Descriptor/Qualifier:	Adenocarcinoma / genetics, pathology Adenoma / genetics, pathology Genes, Tumor Suppressor Genetic Predisposition to Disease Humans Kidney Neoplasms / genetics, pathology

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