| Pathological implications of cell cycle re-entry in Alzheimer disease. | |
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MedLine Citation:
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PMID: 20584423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The complex neurodegeneration underlying Alzheimer disease (AD), although incompletely understood, is characterised by an aberrant re-entry into the cell cycle in neurons. Pathological evidence, in the form of cell cycle markers and regulatory proteins, suggests that cell cycle re-entry is an early event in AD, which precedes the formation of amyloid-beta plaques and neurofibrillary tangles (NFTs). Although the exact mechanisms that induce and mediate these cell cycle events in AD are not clear, significant advances have been made in further understanding the pathological role of cell cycle re-entry in AD. Importantly, recent studies indicate that cell cycle re-entry is not a consequence, but rather a cause, of neurodegeneration, suggesting that targeting of cell cycle re-entry may provide an opportunity for therapeutic intervention. Moreover, multiple inducers of cell cycle re-entry and their interactions in AD have been proposed. Here, we review the most recent advances in understanding the pathological implications of cell cycle re-entry in AD. |
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Authors:
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David J Bonda; Hyun-pil Lee; Wataru Kudo; Xiongwei Zhu; Mark A Smith; Hyoung-gon Lee |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-06-29 |
Journal Detail:
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Title: Expert reviews in molecular medicine Volume: 12 ISSN: 1462-3994 ISO Abbreviation: Expert Rev Mol Med Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-09-23 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 100939725 Medline TA: Expert Rev Mol Med Country: England |
Other Details:
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Languages: eng Pagination: e19 Citation Subset: IM |
Affiliation:
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Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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etiology*,
pathology* Animals Cell Cycle / physiology* Humans Models, Biological Neurons / cytology |
| Grant Support | |
ID/Acronym/Agency:
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AG028679/AG/NIA NIH HHS; AG030096/AG/NIA NIH HHS; AG031364/AG/NIA NIH HHS; R01 AG028679-03/AG/NIA NIH HHS; R01 AG028679-04/AG/NIA NIH HHS; R21 AG030096-02/AG/NIA NIH HHS; R21 AG031364-02/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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