Document Detail

Pathological gambling in Parkinson's disease: disease related or drug related?
MedLine Citation:
PMID:  21651329     Owner:  NLM     Status:  In-Data-Review    
Pathological gambling and other impulse-control disorders occur in susceptible Parkinson's disease patients during dopaminergic therapy, particularly in association with dopamine agonists. Additional factors such as age at onset play an important role, and predisposing personality traits have been identified both in treated patients, as well as in patients even before therapy is initiated. The contributions of specific allelic polymorphisms of the dopamine receptor and transporter genes were also tested as predictors of adverse effects of dopaminergic therapy but results are not conclusive. Recent imaging studies have shed light on the mechanism underlying pathological gambling. Resting-state brain perfusion of Parkinson's disease gamblers showed higher activity in 'limbic' areas associated with addictive processes. More importantly, severity of this behavior is associated with the impaired functioning of brain regions that are involved in 'top-down' cognitive monitoring and inhibition of inappropriate behaviors. This evidence is consistent with a significant contribution of disease-related factors.
Daniela Calandrella; Angelo Antonini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of neurotherapeutics     Volume:  11     ISSN:  1744-8360     ISO Abbreviation:  Expert Rev Neurother     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129944     Medline TA:  Expert Rev Neurother     Country:  England    
Other Details:
Languages:  eng     Pagination:  809-14     Citation Subset:  IM    
Parkinson's Disease Department, Clinic San Pio X, Milan, Italy.
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