| Pathological fracture as the presenting feature in pediatric osteosarcoma. | |
| | |
MedLine Citation:
|
PMID: 23281226 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Pathological fracture is an uncommon presentation in patients with long bone osteosarcoma. PROCEDURES: We retrospectively reviewed the database of all patients with histologically proven osteosarcoma under the age of 18 years from 1991 to 2011 in a tertiary pediatric oncology referral center. Five patients with pathological fractures as the first presentation of osteosarcoma were identified. The treatment strategies and complications were evaluated. Ten sex-, age-, and site- matched osteosarcoma patients without pathological fracture were selected as controls. The incidence of distant metastases and outcome, including local recurrence and survival, were compared between the index (with pathological fracture) and the control (without pathological fracture) groups. RESULTS: In the index group, all five patients were boys and the mean age of onset was 13.1 years (range 9.2-14.9). Three patients (60%, 3/5) received amputation and two (40%) had wide local excision of the tumor. Pathological fracture group showed higher rate of lung (60% vs. 10%, P = 0.04) and bone (60% vs. 10%, P = 0.04) metastases at presentation, and shorter overall 5-year survival (P = 0.04) than the control group. There was no significant difference of local recurrence (20%, P = 1.00) between these two groups regardless of the type of operation. CONCLUSION: Osteosarcoma complicated by pathological fracture as first presentation had higher incidence of lung and bone metastases at presentation and worse survival rate when compared with patients without pathological fracture. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. |
| | |
Authors:
|
Ryan K L Lee; Winnie C W Chu; Joyce H Y Leung; Frankie W T Cheng; C K Li |
Related Documents
:
|
8382276 - Suramin is a potent inhibitor of calcemic hormone- and growth factor-induced bone resor... 11885466 - Enlargement of periosteocytic lacunae associated to mechanical forces. 23384866 - Role of locking plates in treatment of difficult ununited fractures: a clinical study. 23433996 - Pediatric nasal bone fractures: does delayed treatment really lead to adverse outcomes? 3189526 - New first metatarsal (skx 5017) from swartkrans and the gait of paranthropus robustus. 8775116 - Evaluation of the arthroscopic valgus instability test of the elbow. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-31 |
Journal Detail:
|
Title: Pediatric blood & cancer Volume: - ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2013-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Imaging and Interventional Radiology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, Hong Kong. leekalok2909@yahoo.com.hk. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of r...
Next Document: Synthesis of Various Saturated and Unsaturated N-Heterocyclic Carbene Precursors by Triflic Anhydrid...