Document Detail

Pathological changes and myocardial remodelling related to the mode of shunting following surgical palliation for hypoplastic left heart syndrome.
MedLine Citation:
PMID:  18588727     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The modification of placing the shunt from the right ventricle to the pulmonary arteries, also known as Sano procedure, has allegedly improved results over the short term in surgical palliation of hypoplastic left heart syndrome with the Norwood procedure. With this in mind, we reviewed autopsied specimens from neonates and children who did not survive after either a classic arterio-pulmonary shunt, or the modified procedure with the shunt placed from the right ventricle to the pulmonary arteries, so as to evaluate the pathological substrates of the remodelling of the systemic right ventricle, assessing any differences induced by the 2 techniques. METHODS: We obtained the hearts from 11 patients with neonatal diagnosis of hypoplastic left heart syndrome who died after the first or second stages of the Norwood sequence of operations, comparing them with 6 normal hearts matched for age and weight. Macroscopic, microscopic and morphometric analysis were performed on each specimen, evaluating the diameter of the myocytes, extracellular matrix remodelling in terms of fibrosis and type of collagen, and vascularization in terms of capillary density. RESULTS: Hypertrophy of the myocytes was significantly increased in the hearts from patients having either a classic arterio-pulmonary or the ventriculo-pulmonary modification of the shunt compared to controls (p < 0.05). Myocardial fibrosis was increased in those having a shunt placed from the right ventricle to the pulmonary arteries when compared to the other 2 groups. The ratio of collagen I to collagen III was similar in those undergoing a classic arterio-pulmonary shunt compared to controls (0.94), but was lower in those having a shunt placed from the right ventricle to the pulmonary arteries (0.61), with an increase in collagen type III. The density of capillaries was lower in those who had undergone a classic arterial shunt when compared to the others. CONCLUSION: We have shown greater remodelling of the ventricular myocardial extracellular matrix in patients having a shunt from the right ventricle to the pulmonary arteries when compared to those having a classic arterio-pulmonary shunt, with this remodelling progressing even after the neonatal period. This may influence a later suboptimal ventricular performance.
Massimo A Padalino; Chiara Castellani; Silvia Toffoli; Mila Della Barbera; Ornella Milanesi; Gaetano Thiene; Giovanni Stellin; Annalisa Angelini
Related Documents :
3304027 - Shunt thrombosis prevention in hemodialysis patients--a double-blind, randomized study:...
8617647 - Intraoperative use of subtraction angiography and an ultrasonic aspirator to improve id...
6207387 - Arterial thromboembolic complications of peritoneovenous shunting for malignant ascites.
1622617 - Patent foramen ovale: a nonfunctional embryological remnant or a potential cause of sig...
21559787 - Physiological significance of p2x receptor-mediated vasoconstriction in five different ...
17354637 - Vessel axis tracking using topology constrained surface evolution.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-30
Journal Detail:
Title:  Cardiology in the young     Volume:  18     ISSN:  1047-9511     ISO Abbreviation:  Cardiol Young     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-14     Completed Date:  2008-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200019     Medline TA:  Cardiol Young     Country:  England    
Other Details:
Languages:  eng     Pagination:  415-22     Citation Subset:  IM    
Pediatric and Congenital Cardiovascular Surgery Unit, University of Padua, Medical School, Padua, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Capillaries / pathology
Cause of Death
Collagen / analysis
Fibrosis / pathology
Hypoplastic Left Heart Syndrome / pathology*,  surgery
Infant, Newborn
Myocardium / pathology*
Palliative Care*
Retrospective Studies
Ventricular Remodeling*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Unsuitable readability levels of patient information pertaining to dementia and related diseases: a ...
Next Document:  Towards an anatomically correct repair for anomalous left coronary artery arising from the pulmonary...