| Pathological changes of myocardial cytoskeleton in cardiomyopathic hamster. | |
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MedLine Citation:
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PMID: 7791749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunocytochemical investigation was performed on the cytoskeletal proteins in cardiac tissue of the cardiomyopathic hamster. Male cardiomyopathic UM-X7.1 hamsters at 180 days of age (n = 8) and age- and sex-matched normal BIO-RB hamsters (n = 8) were used in this study. Immunofluorescence microscopy using monoclonal antibodies against desmin, alpha-actinin, titin, and vincullin was employed. The heart weight to body weight ratio was significantly increased in the heart of cardiomyopathic hamster compared with that of normal hamster. In cardiomyopathic hamster, the left ventricular cavity was markedly dilated. Light microscopically, hypertrophy and atrophy of myocytes and myocardial fibrosis were prominently observed in cardiomyopathic myocardium. Immunocytochemically, desmin, alpha-actinin and titin showed the cross striations along the myofibers in normal myocardium. In contrast, in cardiomyopathic myocardium, desmin was irregularly distributed in myocytes and the amount of desmin was increased. Loss of cross striations of alpha-actinin and titin were frequently observed. Immunofluorescence against vinculin was not significantly altered. We conclude that the alterations of cytoskeletal proteins in myocardial cells may relate to decreased myocardial function in cardiomyopathic hamster failing heart. |
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Authors:
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N Kawaguchi; N Fujitani; J Schaper; S Onishi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 144 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-07-25 Completed Date: 1995-07-25 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 75-9 Citation Subset: IM |
Affiliation:
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School of Allied Health Sciences, Faculty of Medicine, Osaka University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actinin
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analysis Animals Body Weight Cardiomyopathies / metabolism, pathology* Cell Size Collagen / analysis Cricetinae Cytoskeletal Proteins / analysis* Cytoskeleton / chemistry*, ultrastructure Desmin / analysis Immunohistochemistry Male Muscle Proteins / analysis Myocardium / chemistry, ultrastructure* Organ Size Protein Kinases* Vinculin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Cytoskeletal Proteins; 0/Desmin; 0/Muscle Proteins; 0/connectin; 11003-00-2/Actinin; 125361-02-6/Vinculin; 9007-34-5/Collagen; EC 2.7.-/Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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