Document Detail

Pathological changes from acute to chronic in experimental spinal cord trauma.
MedLine Citation:
PMID:  619028     Owner:  NLM     Status:  MEDLINE    
The pathological changes occurring in the thoracic spinal cords of 41 cats were studied by light microscopy at 4 hours, 4 weeks, and 4 months after graded transdural trauma. Alterations characteristic of a vascular injury proportionate to the magnitude of the original trauma which results in tissue hypoxia, destruction, and reparation were identified at each interval studied. In more severely injured animals these changes consisted of an initial hemorrhagic infarction followed by the removal of necrotic parenchyma and the development of an adhesive arachnoiditis and intramedullary carvitation. A comparison of the findings in the present investigation with what has been described in postmortem studies of spinal cord injured patients indicates that the response of the spinal cord to non-disruptive trauma is similar in both cases.
F C Wagner; J C VanGilder; G J Dohrmann
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  48     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  92-8     Citation Subset:  AIM; IM    
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MeSH Terms
Axons / pathology
Meninges / pathology
Neuroglia / pathology
Neurons / pathology
Spinal Cord / blood supply,  pathology*
Spinal Cord Injuries / pathology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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