Document Detail


Pathological cerebral oscillatory activity in Parkinson's disease: a critical review on methods, data and hypotheses.
MedLine Citation:
PMID:  17850199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although well-known for more than a century, a sound pathophysiological mechanism for Parkinson's disease (PD) was lacking for a long time. The recent availability of electrophysiological techniques, such as magnetoencephalography, high-resolution electroencephalography and intra- and post-operative recordings in PD patients undergoing deep brain stimulation, allowed new approaches to record neuronal activity. Furthermore, the new application of signal analysis tools, such as the fast Fourier transformation, coherence, phase shifts, as well as causality measures, gave tremendous new insights into mechanisms of frequency-dependent oscillatory coupling. This review highlights these new analysis approaches, reviews the noninvasive magnetoencephalography, electroencephalography and intra- and post-operative data on PD patients, and summarizes the modern hypothesis that PD results from pathological oscillatory synchronization in the human sensorimotor system.
Authors:
Lars Timmermann; Esther Florin; Christiane Reck
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of medical devices     Volume:  4     ISSN:  1743-4440     ISO Abbreviation:  -     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-13     Completed Date:  2007-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230445     Medline TA:  Expert Rev Med Devices     Country:  England    
Other Details:
Languages:  eng     Pagination:  651-61     Citation Subset:  IM    
Affiliation:
University Hospital Cologne, Department of Neurology, Joseph-Stelzmann-Str. 9, 50924 Köln, Germany. lars.timmermann@uk-koeln.de
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MeSH Terms
Descriptor/Qualifier:
Brain / physiopathology*
Electrodes
Electroencephalography*
Humans
Magnetoencephalography*
Parkinson Disease / diagnosis*,  physiopathology*

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