Document Detail

Pathological and biochemical changes induced in mice after intramuscular injection of venom from newborn specimens of the snake Bothrops asper (Terciopelo).
MedLine Citation:
PMID:  1440647     Owner:  NLM     Status:  MEDLINE    
Venom from newborn Bothrops asper snakes has higher lethal, hemorrhagic, edema-forming, proteolytic and defibrinating activities than venom from adult B. asper specimens. Electrophoretic analysis confirmed the variation between these venoms. Intramuscular injection of 100 micrograms of venom from newborn specimens in mice induced defibrination, together with moderate increments of serum levels of lactate dehydrogenase, creatine kinase, hemoglobin and total proteins. A conspicuous hemorrhage developed in injected muscle rapidly after envenomation, probably due to a drastic alteration in capillaries and larger blood vessels. Other histological alterations included moderate myonecrosis, lung collapse and prominent renal damage, characterized by tubular necrosis and hyalinization. Polyvalent antivenom effectively neutralized lethal, hemorrhagic and indirect hemolytic activities of newborn B. asper venom, although requiring higher antivenom doses than neutralization of venom from adult B. asper.
F Chaves; J M Gutiérrez; F Brenes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  30     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-12-08     Completed Date:  1992-12-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1099-109     Citation Subset:  IM    
Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José.
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MeSH Terms
Animals, Newborn / physiology*
Antivenins / pharmacology
Blood Coagulation / drug effects
Crotalid Venoms / enzymology,  toxicity*
Edema / chemically induced,  pathology
Electrophoresis, Polyacrylamide Gel
Enzymes / blood
Hemoglobins / metabolism
Hemolysis / drug effects
Hemorrhage / chemically induced,  pathology
Injections, Intramuscular
Muscles / pathology
Neutralization Tests
Reg. No./Substance:
0/Antivenins; 0/Crotalid Venoms; 0/Enzymes; 0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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