Document Detail


Pathological angiogenesis facilitates tumor cell dissemination and metastasis.
MedLine Citation:
PMID:  20160500     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinically detectable metastases represent an ultimate consequence of the metastatic cascade that consists of distinct processes including tumor cell invasion, dissemination, metastatic niche formation, and re-growth into a detectable metastatic mass. Although angiogenesis is known to promote tumor growth, its role in facilitating early events of the metastatic cascade remains poorly understood. We have recently developed a zebrafish tumor model that enables us to study involvement of pathological angiogenesis in tumor invasion, dissemination and metastasis. This non-invasive in vivo model allows detection of single malignant cell dissemination under both normoxia and hypoxia. Further, hypoxia-induced VEGF significantly facilitates tumor cell invasion and dissemination. These findings demonstrate that VEGF-induced pathological angiogenesis is essential for tumor dissemination and further corroborates potentially beneficial effects of clinically ongoing anti-VEGF drugs for the treatment of various malignancies.
Authors:
Pegah Rouhi; Samantha Lin Chiou Lee; Ziquan Cao; Eva-Maria Hedlund; Lasse Dahl Jensen; Yihai Cao
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-06
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  9     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-06-29     Revised Date:  2010-08-25    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  913-7     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia
Models, Animal
Neoplasm Invasiveness*
Neoplasm Metastasis*
Neovascularization, Pathologic*
Vascular Endothelial Growth Factor A / metabolism
Zebrafish
Chemical
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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