Document Detail

Pathological abnormalities after long-term administration of medroxyprogesterone acetate in a queen.
MedLine Citation:
PMID:  19058986     Owner:  NLM     Status:  MEDLINE    
In this report, multiple abnormalities (bilateral ovarian cysts, cystic endometrial hyperplasia and pyometra (CEH-P), mammary adenoma, fibrosarcoma and cystic-papillary adenocarcinoma) identified in a queen continually administered medroxyprogesterone acetate (MPA) for 9 years are described. An 11-year-old domestic shorthair intact queen was presented for reduced appetite, polyuria, polydipsia, abdominal distension, and mammary mass. Pyometra was diagnosed based upon clinical, ultrasonographic and radiographic examinations. Mastectomy and ovariohysterectomy (OHE) were performed for treatment. Bilateral ovarian cysts were detected during OHE. Histopathologically, follicular ovarian cysts, CEH-P, and benign and neoplastic mammary lesions were identified. We suggest that, the pathological abnormalities may have been attributed to adverse effects of prolonged administration of MPA.
Abdulkadir Keskin; Gulnaz Yilmazbas; Rahsan Yilmaz; Musa O Ozyigit; Ahmet Gumen
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-12-05
Journal Detail:
Title:  Journal of feline medicine and surgery     Volume:  11     ISSN:  1098-612X     ISO Abbreviation:  J. Feline Med. Surg.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-09-10     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  100897329     Medline TA:  J Feline Med Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  518-21     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Uludag, Gorukle 16059, Bursa, Turkey.
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MeSH Terms
Adenocarcinoma, Papillary / chemically induced,  surgery,  veterinary*
Cat Diseases / chemically induced*,  surgery*,  ultrasonography
Contraceptive Agents, Female / adverse effects*
Endometrial Hyperplasia / chemically induced,  surgery,  veterinary
Hysterectomy / adverse effects
Mammary Neoplasms, Animal / chemically induced*,  surgery
Medroxyprogesterone Acetate / adverse effects*
Ovariectomy / adverse effects
Pyometra / chemically induced,  surgery,  veterinary*
Reg. No./Substance:
0/Contraceptive Agents, Female; 71-58-9/Medroxyprogesterone Acetate
Comment In:
J Feline Med Surg. 2010 Sep;12(9):724   [PMID:  20800213 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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