| Pathological study of acute pulmonary toxicity induced by intratracheally instilled Asian sand dust (kosa). | |
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MedLine Citation:
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PMID: 20884819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to investigate acute lung toxicity caused by Asian sand dust. Simulated Asian sand dust collected from the Tennger desert in China (CJ-2 particles) and Asian sand dust collected from the atmosphere in Japan (Tottori particles) were used. Saline suspensions of 50, 200, 800, and 3,000 µg Asian sand dust were intratracheally instilled to ICR mice. Localized accumulation of the dust particles was observed in the bronchioles and the alveoli of the lung tissues; acute inflammatory changes characterized by infiltration of macrophages and neutrophils were observed around the particles. Degenerated alveolar walls and bronchial epithelial cells, as well as a weakened positive immunolabeling for laminin, were observed to be associated with particle attachment. Positive immunolabelings for interleukin-6, tumor necrosis factor-α inducible nitric oxide synthase, and dimeric copper- and zinc-containing superoxide dismutase were observed mainly in the inflammatory cells in the lesions; these findings were not observed in the controls or in areas lacking lesions. These results suggest that Asian sand dust particles caused damage to the lung tissue through a direct physical effect. In addition, secondary released cytokines and oxidative stress generated in the lesion may be involved in the development of the acute lung toxicity. |
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Authors:
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Misaki Naota; Toru Mukaiyama; Akinori Shimada; Atushi Yoshida; Mina Okajima; Takehito Morita; Kenichiro Inoue; Hirohisa Takano |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-30 |
Journal Detail:
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Title: Toxicologic pathology Volume: 38 ISSN: 1533-1601 ISO Abbreviation: Toxicol Pathol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-01-20 Completed Date: 2011-04-19 Revised Date: 2012-01-05 |
Medline Journal Info:
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Nlm Unique ID: 7905907 Medline TA: Toxicol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 1099-110 Citation Subset: IM |
Affiliation:
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Department of Veterinary Pathology, Tottori University, Tottori-shi, Tottori, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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chemically induced*,
metabolism,
pathology Animals Asia Bronchioles / drug effects, metabolism, pathology Cytokines / metabolism Disease Models, Animal Dust* Elements Epithelial Cells / drug effects, metabolism, ultrastructure Intubation, Intratracheal Lung / drug effects*, metabolism, pathology Macrophages / drug effects, pathology Male Mice Mice, Inbred ICR Neutrophils / drug effects, pathology Oxidative Stress / drug effects Particle Size Pulmonary Alveoli / drug effects, metabolism, pathology Silicon Dioxide / chemistry, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Dust; 0/Elements; 7631-86-9/Silicon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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